The body is a machine. Your body gets hot and cold. When your body gets hot you perspire, hot weather makes your hands swell. When it's cold weather your hands shrink. 

The point being if you are using orthopedic grips, the grips may be too big or too small, depending on the weather. I like the orthopedic grips, I find it helps keep the firearm on the black of the target. 

They also seem to help recovering after the shot fires, getting the front sight or red dot back onto the black of the target.

GRIPPING THE GUN

How do you hang onto the gun? Pick up the gun in your non shooting hand and stuff the gun into your non-shooting hand. Then extend your fingers around he grip. The grip should be natural and comfortable to you. Grip equally with your four fingers. (Your four fingers do not include your trigger finger.)